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To create multiple instances, use the base class, OpenInterpreter: 
from interpreter import OpenInterpreter

agent_1 = OpenInterpreter()
agent_1.system_message = "This is a separate instance."

agent_2 = OpenInterpreter()
agent_2.system_message = "This is yet another instance."
For fun, you could make these instances talk to eachother: 
def swap_roles(messages):
    for message in messages:
        if message['role'] == 'user':
            message['role'] = 'assistant'
        elif message['role'] == 'assistant':
            message['role'] = 'user'
    return messages

agents = [agent_1, agent_2]

# Kick off the conversation
messages = [{"role": "user", "message": "Hello!"}]

while True:
    for agent in agents:
        messages = agent.chat(messages)
        messages = swap_roles(messages)